The children, with nationalities from 30 countries including France, Germany, the United States and Britain, are from families with real or suspected links to ISIS.
They are living in three camps in northeast Syria without proper healthcare, food or education, the charity said.
With ISIS depleted and Kurdish-led militia poised to seize the group’s last holdout in eastern Syria, Western capitals are trying to work out what to do with foreign fighters and their wives and children.
“All states whose nationals are trapped in Syria must take responsibility for their citizens,” Save the Children’s Syria response director, Sonia Khush, said in a statement.
“While some states have begun to do so, many countries – including several European countries – have yet to take steps to ensure the safety of the children and their families.”
In some cases, girls recruited by ISIS as children are now mothers themselves. Some of the infants in the camps are merely days or weeks old.
The fate of foreign children stuck in Syria has been highlighted by the case of a teenage mother who this week was stripped of her British citizenship on security grounds after leaving London to join ISIS at 15.
Since January, 560 foreign families, including more than 1,100 children, have entered the camps alongside thousands of Syrian families after fleeing fighting, said Save the Children.
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